Bias in occupational epidemiology studies.


Pearce, N; Checkoway, H; Kriebel, D; (2007) Bias in occupational epidemiology studies. Occupational and environmental medicine, 64 (8). pp. 562-8. ISSN 1351-0711 DOI: https://doi.org/10.1136/oem.2006.026690

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Abstract

The design of occupational epidemiology studies should be based on the need to minimise random and systematic error. The latter is the focus of this paper, and includes selection bias, information bias and confounding. Selection bias can be minimised by obtaining a high response rate (and by appropriate selection of the control group in a case-control study). In general, it is important to ensure that information bias is minimised and is also non-differential (for example, that the misclassification of exposure is not related to disease status) by collecting data in a standardised manner. A major concern in occupational epidemiology studies usually relates to confounding, because exposure has not been randomly allocated, and the groups under study may therefore have different baseline disease risks. For each of these types of bias, the goal should be to avoid the bias by appropriate study design and/or appropriate control in the analysis. However, it is also important to attempt to assess the likely direction and strength of biases that cannot be avoided or controlled.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 17053019
Web of Science ID: 248171600013
URI: http://researchonline.lshtm.ac.uk/id/eprint/1510

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