Borderline tuberculoid leprosy: an immune reconstitution phenomenon in a human immunodeficiency virus-infected person


Lawn, SD; Wood, C; Lockwood, DN; (2003) Borderline tuberculoid leprosy: an immune reconstitution phenomenon in a human immunodeficiency virus-infected person. Clinical infectious diseases, 36 (1). e5-6. ISSN 1058-4838 DOI: https://doi.org/10.1086/344446

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Abstract

Two months after starting highly active antiretroviral treatment (HAART), an individual with human immunodeficiency virus type 1 (HIV-1) infection and profound CD4+ T lymphocytopenia developed several erythematous plaques on his face, which were due to borderline tuberculoid leprosy with reversal reaction. The temporal association between the development of these lesions and changes in blood CD4+ lymphocyte count and plasma HIV-1 load observed during HAART strongly suggests that the presentation of leprosy resulted from immune reconstitution.

Item Type: Article
Keywords: AIDS-Related Opportunistic Infections/immunology, Adult, Anti-HIV Agents/therapeutic use, Antiretroviral Therapy, Highly Active/*adverse effects, CD4 Lymphocyte Count, HIV Infections/complications/drug therapy/*immunology, Human, Immunity/drug effects, Leprosy, Tuberculoid/*etiology/immunology, Male, AIDS-Related Opportunistic Infections, immunology, Adult, Anti-HIV Agents, therapeutic use, Antiretroviral Therapy, Highly Active, adverse effects, CD4 Lymphocyte Count, HIV Infections, complications, drug therapy, immunology, Human, Immunity, drug effects, Leprosy, Tuberculoid, etiology, immunology, Male
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: TB Centre
PubMed ID: 12491222
Web of Science ID: 179916500033
URI: http://researchonline.lshtm.ac.uk/id/eprint/15081

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