Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies?


Doenhoff, MJ; Chiodini, PL; Hamilton, JV; (2004) Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies? Trends in parasitology, 20 (1). pp. 35-39. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2003.10.019

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Abstract

A simple, cheap, sensitive and specific assay for routine diagnosis of schistosome infection is not yet available. This review considers some of the advantages and disadvantages of parasitological microscopy, circulating-antigen detection and antibody-detection methods. Immunoassays for the detection of antibodies reactive against schistosome egg antigens have the potential to be useful in both clinical and epidemiological settings.

Item Type: Article
Keywords: linked-immunosorbent-assay, circulating anodic antigen, keyhole, limpet hemocyanin, mansoni egg antigens, cathodic antigen, helminth infections, parasitic diseases, cross-reactivity, low, transmission, worm burden
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 14700588
Web of Science ID: 188226500011
URI: http://researchonline.lshtm.ac.uk/id/eprint/14995

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