Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults

Ota, MOC; Vekemans, J; Schlegel-Haueter, SE; Fielding, K; Whittle, H; Lambert, PH; McAdam, Kpwj; Siegrist, CA; Marchant, A; (2004) Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults. Vaccine, 22 (3-4). pp. 511-519. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2003.07.020

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New-borns raise limited antibody responses to most T cell- dependent antigens but little is known about neonatal T lymphocyte responses to vaccines. In this study, we compared the immune response induced by the hepatitis B vaccine in new- borns and naive adults. Infants produced markedly higher serum anti-hepatitis B surface (HBs) antibody titres than adults. This was not associated with greater HBs Ag-specific Th2 cytokine responses but with lower primary IFN-gamma responses. At 1 year, the infant memory response to HBs Ag was characterised by higher Th2 responses than those of adults. We conclude that neonatal antibody and T cell responses to hepatitis B vaccine differ from those induced in adults. (C) 2003 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: new-borns, hepatitis B vaccine, Th1/Th2 cells, bacillus-calmette-guerin, ifn-gamma production, t-cell, responses, immune-responses, dendritic cells, vaccine antigens, virus-infection, surface-antigen, in-vivo, mice
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Tropical Epidemiology Group
PubMed ID: 14670334
Web of Science ID: 188301600027
URI: http://researchonline.lshtm.ac.uk/id/eprint/14984


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