Fine Specificity of Serum Antibodies to Plasmodium falciparum Merozoite Surface Protein, PfMSP-1(19), Predicts Protection from Malaria Infection and High-Density Parasitemia


Okech, BA; Corran, PH; Todd, J; Joynson-Hicks, A; Uthaipibull, C; Egwang, TG; Holder, AA; Riley, EM; (2004) Fine Specificity of Serum Antibodies to Plasmodium falciparum Merozoite Surface Protein, PfMSP-1(19), Predicts Protection from Malaria Infection and High-Density Parasitemia. Infection and immunity, 72 (3). pp. 1557-67. ISSN 0019-9567 DOI: https://doi.org/10.1128/iai.72.3.1557-1567.2004

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Abstract

Antibodies to the C terminus of the Plasmodium falciparum merozoite surface protein, PfMSP-1(19), may inhibit merozoite invasion or block the effects of inhibitory antibodies. Here, using a competition enzyme-linked immunosorbent assay and antibody binding to wild-type and mutated recombinant proteins, we show that there are marked variations between individuals in the fine specificity of naturally acquired anti-MSP-1(19) antibodies. Furthermore, although neither the prevalence nor the concentration of total anti-MSP-1(19) antibodies was associated with resistance to malaria in African children, significant associations were observed between antibody fine specificity and subsequent risk of infection and high-density parasitemia during a follow-up period. Thus, the fine specificity of naturally acquired human anti-MSP-1(19) antibodies is crucial in determining their function. Future field studies, including the evaluation of PfMSP-1 vaccine trials, should include assays that explore antibody fine specificity as well as titer.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Population Studies (1974-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Malaria Centre
Population Studies Group
PubMed ID: 14977962
Web of Science ID: 189270800041
URI: http://researchonline.lshtm.ac.uk/id/eprint/14969

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