A novel method of oral fluid collection to monitor immunity to common viral infections


Morris-Cunnington, MC; Edmunds, WJ; Miller, E; Brown, DWG; (2004) A novel method of oral fluid collection to monitor immunity to common viral infections. Epidemiology and infection, 132 (1). pp. 35-42. ISSN 0950-2688 DOI: https://doi.org/10.1017/s0950268803001493

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Abstract

Serological surveys among representative population samples have proved rare given their reliance on invasive sample collection. We therefore completed the first population-based postal survey of immunity in England and Wales using new oral fluid technology. This paper examines the feasibility of this new methodological approach. Nearly 5500 oral fluid samples were collected, with individual demographic and social data via a questionnaire, from persons under 45 years of age recruited through general practices. Instructions were accurately followed with only 1% of samples returned without risk-factor data. The overall response rate was 40%. Response was independently associated with age, sex and location. Response was highest in children aged 5-14 years, adult females and in rural locations. This approach allowed the successful collection of comprehensive individual risk data, but response rates in adults must be improved if oral fluid surveys are to routinely complement serological surveillance.

Item Type: Article
Keywords: Serological surveillance, hepatitis-a, england, population, prevalence, wales, antibody, health, deprivation, nonresponse, Adolescent, Adult, Age Distribution, Antibodies, Viral, analysis, Chickenpox, diagnosis, epidemiology, immunology, Child, Child, Preschool, Cluster Analysis, England, epidemiology, Epstein-Barr Virus Infections, diagnosis, epidemiology, immunology, Feasibility Studies, Female, Hepatitis A, diagnosis, epidemiology, immunology, Herpes Simplex, diagnosis, epidemiology, immunology, Human, Male, Population Surveillance, methods, Postal Service, Questionnaires, Risk Factors, Saliva, virology, Seroepidemiologic Studies, Sex Distribution, Specimen Handling, methods, Support, Non-U.S. Gov't, Virus Diseases, diagnosis, epidemiology, immunology, Wales, epidemiology
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 14979587
Web of Science ID: 220290200006
URI: http://researchonline.lshtm.ac.uk/id/eprint/14847

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