Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease


Khan, NL; Katzenschlager, R; Watt, H; Bhatia, KP; Wood, NW; Quinn, N; Lees, AJ; (2004) Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease. Neurology, 62 (7). pp. 1224-6. ISSN 0028-3878

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Abstract

The authors studied whether olfactory dysfunction is present in parkin disease using the University of Pennsylvania Smell Identification Test (UPSIT). The mean UPSIT score in parkin patients was 27.3 (95% CI 24.4 to 30.2). This did not differ from the normal group mean of 29.4 (95% CI 28.0 to 30.7; p = 0.22) but was higher than the Parkinson disease group (mean 14.3; 95% CI 12.2 to 19.5; p < 0.0001) and the parkin-negative group (mean 17.1; 95% CI 14.8 to 16.3; p < 0.0001) values. Parkin disease may be a distinct and separate entity from Parkinson disease.

Item Type: Article
Keywords: Juvenile parkinsonism, gene, pathogenesis
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 15079034
Web of Science ID: 220769300039
URI: http://researchonline.lshtm.ac.uk/id/eprint/14838

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