Aromatase inhibitors as adjuvant therapies in patients with breast cancer


Coombes, RC; Gibson, L; Hall, E; Emson, M; Bliss, J; (2003) Aromatase inhibitors as adjuvant therapies in patients with breast cancer. The Journal of steroid biochemistry and molecular biology, 86 (3-5). pp. 309-11. ISSN 0960-0760 DOI: https://doi.org/10.1016/S0960-0760(03)00372-8

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Abstract

There is increasing evidence that endocrine therapy has an important role in patients with oestrogen receptor positive breast cancer. Several large meta-analyses have reinforced the value of both ovarian ablation and tamoxifen in improving survival. Over the past decade, aromatase inhibitors have become the treatment of choice for second-line therapy of metastatic breast cancer, and the third generation inhibitors have now an established reputation for good patient tolerability. Early studies indicated that aminoglutethimide/hydrocortisone could benefit postmenopausal patients with primary breast cancer, and in 2001, the ATAC study showed that the third generation aromatase inhibitor, anastrozole, seemed superior to tamoxifen in that anastrozole-treated patients had a longer disease-free survival. Other studies will report on the relative merits of the steroidal inhibitor exemestane as well as non-steroidal letrozole. The exact duration and sequencing of treatment, together with the long-term effects on bone are at present, unknown.

Item Type: Article
Keywords: Aromatase, Breast Neoplasms, Chemotherapy, Adjuvant, Clinical Trials, Enzyme Inhibitors, Human, Support, Non-U.S. Gov't, Treatment Outcome, Aromatase, antagonists & inhibitors, Breast Neoplasms, drug therapy, enzymology, pathology, Chemotherapy, Adjuvant, Clinical Trials, Enzyme Inhibitors, pharmacology, therapeutic use, Human, Support, Non-U.S. Gov't, Treatment Outcome
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 14623526
Web of Science ID: 186912500014
URI: http://researchonline.lshtm.ac.uk/id/eprint/14754

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