Effect of azithromycin mass drug administration for trachoma on spleen rates in Gambian children.


Hart, JD; Edwards, T; Burr, SE; Harding-Esch, EM; Takaoka, K; Holland, MJ; Sillah, A; Mabey, DC; Bailey, RL; (2014) Effect of azithromycin mass drug administration for trachoma on spleen rates in Gambian children. Tropical medicine & international health , 19 (2). pp. 207-11. ISSN 1360-2276 DOI: 10.1111/tmi.12234

Full text not available from this repository. (Request a copy)

Abstract

OBJECTIVE: To assess the effect of azithromycin mass drug administration regimens on spleen rates in children aged 0-5 years.<br/> METHODS: Clinical assessment of spleen size was carried out during a cluster-randomised trial of azithromycin mass treatment for trachoma elimination in The Gambia. Twenty-four communities received three annual mass treatments with azithromycin, and 24 communities received treatment at baseline only.<br/> RESULTS: At the 30-month follow-up, 3646 children aged 0-5 years had spleen examination and measurement. Palpable splenomegaly was significantly lower in annually treated vs. baseline-only treatment communities and in treated vs. untreated children at 24 months in the annual treatment arm.<br/> CONCLUSION: The results suggest an effect of azithromycin on spleen rates at the individual level and are most plausibly due to the antimalarial effects of azithromycin.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Antimicrobial Resistance Centre (AMR)
Centre for Maternal, Reproductive and Child Health (MARCH)
Neglected Tropical Diseases Network
Tropical Epidemiology Group
PubMed ID: 24433194
Web of Science ID: 329822400011
URI: http://researchonline.lshtm.ac.uk/id/eprint/1472186

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
330Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item