Effect of azithromycin mass drug administration for trachoma on spleen rates in Gambian children.
Hart, JD; Edwards, T; Burr, SE; Harding-Esch, EM; Takaoka, K; Holland, MJ; Sillah, A; Mabey, DC; Bailey, RL; (2014) Effect of azithromycin mass drug administration for trachoma on spleen rates in Gambian children. Tropical medicine & international health , 19 (2). pp. 207-11. ISSN 1360-2276 DOI: 10.1111/tmi.12234
OBJECTIVE: To assess the effect of azithromycin mass drug administration regimens on spleen rates in children aged 0-5 years.<br/> METHODS: Clinical assessment of spleen size was carried out during a cluster-randomised trial of azithromycin mass treatment for trachoma elimination in The Gambia. Twenty-four communities received three annual mass treatments with azithromycin, and 24 communities received treatment at baseline only.<br/> RESULTS: At the 30-month follow-up, 3646 children aged 0-5 years had spleen examination and measurement. Palpable splenomegaly was significantly lower in annually treated vs. baseline-only treatment communities and in treated vs. untreated children at 24 months in the annual treatment arm.<br/> CONCLUSION: The results suggest an effect of azithromycin on spleen rates at the individual level and are most plausibly due to the antimalarial effects of azithromycin.<br/>
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