Validation of the SF-36 in patients with endometriosis.

Stull, DE; Wasiak, R; Kreif, N; Raluy, M; Colligs, A; Seitz, C; Gerlinger, C; (2013) Validation of the SF-36 in patients with endometriosis. Quality of life research. ISSN 0962-9343 DOI:

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OBJECTIVES Endometriosis presents with significant pain as the most common symptom. Generic health measures can allow comparisons across diseases or populations. However, the Medical Outcomes Study Short Form 36 (SF-36) has not been validated for this disease. The goal of this study was to validate the SF-36 (version 2) for endometriosis. METHODS Using data from two clinical trials (N = 252 and 198) of treatment for endometriosis, a full complement of psychometric analyses was performed. Additional instruments included a pain visual analog scale (VAS); a physician-completed questionnaire based on patient interview (modified Biberoglu and Behrman-B&B); clinical global impression of change (CGI-C); and patient satisfaction with treatment. RESULTS Bodily pain (BP) and the Physical Component Summary Score (PCS) were correlated with the pain VAS at baseline and over time and the B&B at baseline and end of study. In addition, those who had the greatest change in BP and PCS also reported the greatest change on CGI-C and patient satisfaction with treatment. Other subscales showed smaller, but significant, correlations with change in the pain VAS, CGI-C, and patient satisfaction with treatment. CONCLUSIONS The SF-36-particularly BP and the PCS-appears to be a valid and responsive measure for endometriosis and its treatment.

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Health Services Research and Policy
PubMed ID: 23851974
Web of Science ID: 330831100012


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