Non-eosinophilic asthma: importance and possible mechanisms.


Douwes, J; Gibson, P; Pekkanen, J; Pearce, N; (2002) Non-eosinophilic asthma: importance and possible mechanisms. Thorax, 57 (7). pp. 643-8. ISSN 0040-6376 DOI: https://doi.org/10.1136/thorax.57.7.643

Full text not available from this repository. (Request a copy)

Abstract

There is increasing evidence that inflammatory mechanisms other than eosinophilic inflammation may be involved in producing the final common pathway of enhanced bronchial reactivity and reversible airflow obstruction that characterises asthma. A review of the literature has shown that, at most, only 50% of asthma cases are attributable to eosinophilic airway inflammation. It is hypothesised that a major proportion of asthma is based on neutrophilic airway inflammation, possibly triggered by environmental exposure to bacterial endotoxin, particulate air pollution, and ozone, as well as viral infections. If there are indeed two (or more) subtypes of asthma, and if non-eosinophilic (neutrophil mediated) asthma is relatively common, this would have major consequences for the treatment and prevention of asthma since most treatment and prevention strategies are now almost entirely focused on allergic/eosinophilic asthma and allergen avoidance measures, respectively. It is therefore important to study the aetiology of asthma further, including the underlying inflammatory profiles.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 12096210
Web of Science ID: 176950100016
URI: http://researchonline.lshtm.ac.uk/id/eprint/1458

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
293Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item