Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans.


Elliott, AM; Kyosiimire, J; Quigley, MA; Nakiyingi, J; Watera, C; Brown, M; Joseph, S; French, N; Gilks, CF; Whitworth, JA; (2004) Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans. Transactions of the Royal Society of Tropical Medicine and Hygiene, 97 (4). pp. 477-80. ISSN 0035-9203 DOI: 10.1016/S0035-9203(03)90096-4

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Abstract

It has been suggested that type 1 immune responses protect against tuberculosis (TB), while type 2 responses, such as those induced by helminths, may suppress protective responses and increase susceptibility to TB. Factors associated with progression to active TB were investigated in a cohort of HIV-1-infected Ugandan adults, a group at high risk of TB. High rates of subsequent progression to active TB were associated with eosinophil counts > or = 0.4 x 10(9)/L at enrolment. Eosinophilia at enrolment was associated with male gender, low socio-economic status, high CD4+ T cell counts, and schistosomiasis, but adjusting for these factors did not explain the association of eosinophilia with progression to active TB (adjusted rate ratio = 2.76, P = 0.004). Eosinophilia is most likely to be indicative of a type 2 immune response induced by helminth infection in this Ugandan cohort, but the mechanism of the observed association between eosinophilia and risk of TB remains to be determined.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
TB Centre
PubMed ID: 15259486
Web of Science ID: 222754700029
URI: http://researchonline.lshtm.ac.uk/id/eprint/14573

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