New World cutaneous leishmaniasis in returned travellers: treatment failures using intravenous sodium stibogluconate


Lawn, SD; Yardley, V; Vega-Lopez, F; Watson, J; Lockwood, DN; (2003) New World cutaneous leishmaniasis in returned travellers: treatment failures using intravenous sodium stibogluconate. Transactions of the Royal Society of Tropical Medicine and Hygiene, 97 (4). p. 443. ISSN 0035-9203 DOI: 10.1016/S0035-9203(03)90084-8

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Abstract

Treatment outcome was determined among a cohort of travellers who returned to the UK between February 2000 and February 2001 with New World cutaneous leishmaniasis caused by species of the Leismania (Viannia) subgenus. Among 18 patients who completed treatment with 20 mg/kg/d of i.v. sodium stibogluconate (NaSb) for 20 d, early relapse of disease occurred in 2 patients with regional dissemination in 1 and mucocutaneous involvement in the other. Drug susceptibility testing in vitro of the clinical isolate from 1 of these patients confirmed tolerance to high concentrations of NaSb.

Item Type: Article
Keywords: cutaneous leishmainasis, Leishmania (Viannia) spp., sodium, stibogluconate, treatment failure, drug resistance, travel, medicine, Pentostam, efficacy, invitro, susceptibility, therapy, safety
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Leishmaniasis Group
PubMed ID: 15259478
Web of Science ID: 222754700021
URI: http://researchonline.lshtm.ac.uk/id/eprint/14442

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