Intercontinental spread of pyrimethamine-resistant malaria.
Roper, C; Pearce, R; Nair, S; Sharp, B; Nosten, F; Anderson, T; (2004) Intercontinental spread of pyrimethamine-resistant malaria. Science (New York, NY), 305 (5687 ). 1124 . ISSN 0036-8075 DOI: 10.1126/science.1098876
Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.
|Faculty and Department:||Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology|
|Research Centre:||Antimicrobial Resistance Centre (AMR)
|Web of Science ID:||223557400037|
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