Intercontinental spread of pyrimethamine-resistant malaria.


Roper, C; Pearce, R; Nair, S; Sharp, B; Nosten, F; Anderson, T; (2004) Intercontinental spread of pyrimethamine-resistant malaria. Science (New York, NY), 305 (5687 ). 1124 . ISSN 0036-8075 DOI: 10.1126/science.1098876

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Abstract

Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Antimicrobial Resistance Centre (AMR)
Malaria Centre
PubMed ID: 15326348
Web of Science ID: 223557400037
URI: http://researchonline.lshtm.ac.uk/id/eprint/14423

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