Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study.

Sadarangani, M; Seaton, C; Scott, JA; Ogutu, B; Edwards, T; Prins, A; Gatakaa, H; Idro, R; Berkley, JA; Peshu, N; Neville, BG; Newton, CR; (2008) Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study. Lancet neurology, 7 (2). pp. 145-50. ISSN 1474-4422 DOI:

Text - Published Version

Download (113kB) | Preview


BACKGROUND Convulsive status epilepticus (CSE) is the most common neurological emergency in childhood and is often associated with fever. In sub-Saharan Africa, the high incidence of febrile illnesses might influence the incidence and outcome of CSE. We aimed to provide data on the incidence, causes, and outcomes of childhood CSE in this region. METHODS Between March, 2006, and June, 2006, we studied all children who had been admitted with CSE to a Kenyan rural district hospital in 2002 and 2003. Confirmed CSE had been observed directly; probable CSE was inferred from convulsions on arrival, requirement for phenobarbital or phenytoin, or coma with a recent history of seizures. We estimated the incidence with linked demographic surveillance, and risk factors for death and neurological sequelae were analysed by multivariable analysis. FINDINGS Of 388 episodes of CSE, 155 (40%) were confirmed CSE and 274 (71%) were caused by an infection. The incidence of confirmed CSE was 35 (95% CI 27-46) per 100,000 children per year overall, and was 52 (21-107) and 85 (62-114) per 100,000 per year in children aged 1-11 months and 12-59 months, respectively. The incidence of all CSE was 268 (188-371) and 227 (189-272) per 100,000 per year in these age-groups. 59 (15%) children died in hospital, 81 (21%) died during long-term follow-up, and 46 (12%) developed neurological sequelae. Mortality of children with confirmed CSE while in hospital was associated with bacterial meningitis (adjusted relative risk [RR]=2.6; 95% CI 1.4-4.9) and focal onset seizures (adjusted RR=2.4; 1.1-5.4), whereas neurological sequelae were associated with hypoglycaemia (adjusted RR=3.5; 1.8-7.1) and age less than 12 months (adjusted RR=2.5; 1.2-5.1). INTERPRETATION Prevention of infections and appropriate early management of seizures might reduce the incidence and improve the outcome of CSE in children in sub-Saharan Africa.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 18248771


Download activity - last 12 months
Downloads since deposit
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item