Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo.


Bausch, DG; Borchert, M; Grein, T; Roth, C; Swanepoel, R; Libande, ML; Talarmin, A; Bertherat, E; Muyembe-Tamfum, JJ; Tugume, B; Colebunders, R; Kondé, KM; Pirad, P; Olinda, LL; Rodier, GR; Campbell, P; Tomori, O; Ksiazek, TG; Rollin, PE; (2003) Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo. Emerging infectious diseases, 9 (12). pp. 1531-7. ISSN 1080-6040 DOI: https://doi.org/10.3201/eid0912.030355

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Abstract

: We conducted two antibody surveys to assess risk factors for Marburg hemorrhagic fever in an area of confirmed Marburg virus transmission in the Democratic Republic of the Congo. Questionnaires were administered and serum samples tested for Marburg-specific antibodies by enzyme-linked immunosorbent assay. Fifteen (2%) of 912 participants in a general village cross-sectional antibody survey were positive for Marburg immunoglobulin G antibody. Thirteen (87%) of these 15 were men who worked in the local gold mines. Working as a miner (odds ratio [OR] 13.9, 95% confidence interval [CI] 3.1 to 62.1) and receiving injections (OR 7.4, 95% CI 1.6 to 33.2) were associated with a positive antibody result. All 103 participants in a targeted antibody survey of healthcare workers were antibody negative. Primary transmission of Marburg virus to humans likely occurred via exposure to a still unidentified reservoir in the local mines. Secondary transmission appears to be less common with Marburg virus than with Ebola virus, the other known filovirus.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 14720391
Web of Science ID: 187247600004
URI: http://researchonline.lshtm.ac.uk/id/eprint/14306

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