Stromal cells direct local differentiation of regulatory dendritic cells.


Svensson, M; Maroof, A; Ato, M; Kaye, PM; (2004) Stromal cells direct local differentiation of regulatory dendritic cells. Immunity, 21 (6). pp. 805-16. ISSN 1074-7613 DOI: https://doi.org/10.1016/j.immuni.2004.10.012

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Abstract

CD11c(hi) dendritic cells (DC) play an essential role during the initiation of cell-mediated immunity. Recently, CD11c(lo)CD45RB(hi) DC with regulatory properties have been described. However, the origins of regulatory DC are poorly understood. Here, we show that spleen-derived stromal cells promote selective development of CD11c(lo)CD45RB(+) IL-10-producing regulatory DC from lineage-negative c-kit(+) progenitor cells. These DC have the capacity to suppress T cell responses and induce IL-10-producing regulatory T cells in vitro and to induce antigen-specific tolerance in vivo. Furthermore, stromal cells from mice infected with Leishmania donovani more effectively supported differentiation of these highly potent regulatory DC. The ability of tissue stromal cells to direct the development of DC with a regulatory phenotype thus provides a new mechanism for local immune regulation.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Leishmaniasis Group
PubMed ID: 15589169
Web of Science ID: 225901600008
URI: http://researchonline.lshtm.ac.uk/id/eprint/14072

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