Olfactory function distinguishes vascular parkinsonism from Parkinson's disease


Katzenschlager, R; Zijlmans, J; Evans, A; Watt, H; Lees, AJ; (2004) Olfactory function distinguishes vascular parkinsonism from Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. p. 1749. ISSN 0022-3050 DOI: 10.1136/jnnp.2003.035287

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Abstract

Objective: To compare olfactory function in vascular parkinsonism and Parkinson's disease diagnosed according to published clinical diagnostic criteria. Methods: The University of Pennsylvania smell identification test (UPSIT) was carried out in 14 patients with vascular parkinsonism, 18 with Parkinson's disease, and 27 normal controls matched for age, sex, and smoking status. Results: UPSIT scores in vascular parkinsonism (mean 26.1, 95% confidence interval, 23.1 to 29.0) were significantly better than in Parkinson's disease (mean 17.1 (14.5 to 19.7)) (p<0.0001), and did not differ from the healthy controls (mean 27.6 (25.8 to 29.4)) (p = 0.32). Conclusions: Testing olfactory function may be helpful in differentiating vascular parkinsonism from Parkinson's disease.

Item Type: Article
Keywords: Diagnosis, identification, dysfunction, disorder, entity, smell, signs, body, Aged, Aged, 80 and over, Case-Control Studies, Cerebrovascular Disorders, complications, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Olfaction Disorders, etiology, Parkinson Disease, complications, diagnosis, Parkinsonian Disorders, complications, diagnosis, physiopathology, Predictive Value of Tests, Sensitivity and Specificity, Smell
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 15548497
Web of Science ID: 225162400025
URI: http://researchonline.lshtm.ac.uk/id/eprint/14052

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