The burden of infection with herpes simplex virus type 1 and type 2: Seroprevalence study in Estonia

Uuskula, A; Nygard-Kibur, M; Cowan, FM; Mayaud, P; French, RS; Robinson, JNR; Brown, DWG; (2004) The burden of infection with herpes simplex virus type 1 and type 2: Seroprevalence study in Estonia. Scandinavian journal of infectious diseases, 36 (10). pp. 727-32. ISSN 0036-5548 DOI:

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Information on age- and gender-specific prevalence of herpes simplex virus (HSV) types 1 and 2 infections is crucial to guide genital herpes control strategies. Such data are not available from the newly independent Eastern European countries. We present of study of the age- and gender-specific prevalence of HSV-1 and HSV-2 in low risk populations in Estonia. Serum samples from 1016 children, 794 first trimester antenatal women, and 1036 blood donors (462M, 574F) were tested for HSV IgG antibodies by type-specific HSV-1 and HSV-2 assays. High seroprevalence rates of HSV-1 among children, pregnant women and (non-paid) blood donors were found. HSV-2 infection was not detected among boys. Gender differences in HSV-2 seroprevalence rates among people of reproductive age were observed: higher rates were recorded among pregnant women (23%) and female blood donors (21%), compared to 11% among male blood donors. HSV-1 seroprevalence was high in adults. HSV-2 seroprevalence was higher among females than males and increased substantially with age. HSV-2 prevalence in these non-high risk populations was relatively high, and may indicate a risk for an impending sexually- and STI- driven HIV epidemic.

Item Type: Article
Keywords: Sexually-transmitted-diseases, human-immunodeficiency-virus, genital herpes, hiv-infection, eastern-europe, central-asia, risk-factors, antibodies, association, prevalence, Adolescent, Adult, Age Distribution, Child, Child, Preschool, Communicable Disease Control, organization & administration, Comparative Study, Confidence Intervals, Cross-Sectional Studies, Estonia, epidemiology, Female, Herpes Genitalis, diagnosis, epidemiology, Herpes Simplex, diagnosis, epidemiology, Herpesvirus 1, Human, isolation & purification, Herpesvirus 2, Human, isolation & purification, Humans, Logistic Models, Male, Odds Ratio, Pregnancy, Research Support, Non-U.S. Gov't, Risk Assessment, Seroepidemiologic Studies, Sex Distribution
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
PubMed ID: 15513398
Web of Science ID: 224990100005


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