Prognostic importance of survivin in breast cancer.


Kennedy, SM; O'Driscoll, L; Purcell, R; Fitz-Simon, N; McDermott, EW; Hill, AD; O'Higgins, NJ; Parkinson, M; Linehan, R; Clynes, M; (2003) Prognostic importance of survivin in breast cancer. British journal of cancer, 88 (7). pp. 1077-83. ISSN 0007-0920 DOI: https://doi.org/10.1038/sj.bjc.6600776

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Abstract

Survivin is a member of the inhibitor of apoptosis (IAP) family, and is also involved in the regulation of cell division. Survivin is widely expressed in foetal tissues and in human cancers, but generally not in normal adult tissue. This study examined the expression of surviving protein in a series of 293 cases of invasive primary breast carcinoma. Survivin immunoreactivity was assessed using two different polyclonal antibodies, and evaluated semiquantitatively according to the percentage of cells demonstrating distinct nuclear and/or diffuse cytoplasmic staining. Overall, 60% of tumours were positive for survivin: 31% demonstrated nuclear staining only, 13% cytoplasmic only, and 16% of tumour cells demonstrated both nuclear and cytoplasmic staining. Statistical analysis revealed that survivin expression was independent of patient's age, tumour size, histological grade, nodal status, and oestrogen receptor status. In multivariate analysis, nuclear survivin expression was a significant independent prognostic indicator of favourable outcome both in relapse-free and overall survival (P<0.001 and P=0.01, respectively). In conclusion, our results show that survivin is frequently overexpressed in primary breast cancer. Nuclear expression is most common and is an independent prognostic indicator of good prognosis.

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
PubMed ID: 12671708
Web of Science ID: 182663700017
URI: http://researchonline.lshtm.ac.uk/id/eprint/1391

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