Malaria vaccine research and development: the role of the WHO MALVAC committee.


Targett, GA; Moorthy, VS; Brown, GV; (2013) Malaria vaccine research and development: the role of the WHO MALVAC committee. Malar J, 12 (1). p. 362. ISSN 1475-2875 DOI: 10.1186/1475-2875-12-362

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Abstract

The WHO Malaria Vaccine Advisory Committee (MALVAC) provides advice to WHO on strategic priorities, activities and technical issues related to global efforts to develop vaccines against malaria. MALVAC convened a series of meetings to obtain expert, impartial consensus views on the priorities and best practice for vaccine-related research and development strategies. The technical areas covered during these consultations included: guidance on clinical trial design for candidate sporozoite and asexual blood stage vaccines; measures of efficacy of malaria vaccines in Phase IIb and Phase III trials; standardization of immunoassays; the challenges of developing assays and designing trials for interventions against malaria transmission; modelling impact of anti-malarial interventions; whole organism malaria vaccines, and Plasmodium vivax vaccine-related research and evaluation. These informed discussions and opinions are summarized here to provide guidance on harmonization of strategies to help ensure high standards of practice and comparability between centres and the outcome of vaccine trials.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 24112689
Web of Science ID: 329098600003
URI: http://researchonline.lshtm.ac.uk/id/eprint/1366898

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