Eligibility for isoniazid preventive therapy in South african gold mines.


Lewis, JJ; Fielding, KL; Grant, AD; Chihota, VN; Popane, F; Luttig, M; Muller, D; Coetzee, L; Churchyard, GJ; (2013) Eligibility for isoniazid preventive therapy in South african gold mines. PLoS One, 8 (11). e81376. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0081376

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Abstract

SETTING The "Thibela TB" cluster randomised trial of community-wide isoniazid preventive therapy (IPT) to reduce tuberculosis incidence in the South African gold mines. OBJECTIVES To determine the proportion of participants eligible for IPT and the reasons and risk factors for ineligibility, to inform the scale-up of IPT. DESIGN Cross-sectional survey of participants in intervention clusters (mine shafts) consenting to tuberculosis screening and assessment for eligibility to start IPT. RESULTS Among 27,126 consenting participants, 94.7% were male, the median age was 41 years, 12.2% reported previous tuberculosis, 0.6% reported ever taking IPT and 2.5% reported currently taking antiretroviral therapy. There were 24,430 (90.1%) assessed as eligible to start IPT, of whom 23,659 started IPT. The most common reasons for ineligibility were having suspected tuberculosis that was subsequently confirmed by a positive smear and/or culture (n=705), excessive alcohol consumption (n=427) and being on tuberculosis treatment at time of initial screen (n=241). Ineligibility was associated with factors including older age, female gender, prior history of tuberculosis and being in "HIV care". However, at least 78% were eligible for IPT in all of these sub-groups. CONCLUSIONS The vast majority of participants in this community-wide intervention were eligible for IPT.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Evaluation
TB Centre
Tropical Epidemiology Group
PubMed ID: 24244741
Web of Science ID: 327143800181
URI: http://researchonline.lshtm.ac.uk/id/eprint/1366895

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