Successful liposomal amphotericin B treatment of Leishmania braziliensis cutaneous leishmaniasis.
Brown, M;
Noursadeghi, M;
Boyle, J;
Davidson, RN;
(2005)
Successful liposomal amphotericin B treatment of Leishmania braziliensis cutaneous leishmaniasis.
The British journal of dermatology, 153 (1).
pp. 203-205.
ISSN 0007-0963
DOI: https://doi.org/10.1111/j.1365-2133.2005.06670.x
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Existing systemic treatments for New World cutaneous leishmaniasis (CL) caused by Leishmania (vianna) braziliensis are unsatisfactory. Liposomal amphotericin B has been used extensively for the treatment of visceral leishmaniasis, but in few cases of CL, and an appropriate regimen for CL has not been described. We successfully treated a patient with multiple L. braziliensis CL lesions acquired in Belize. Liposomal amphotericin B (AmBisome) was given to our patient as an inpatient for seven daily doses of 3 mg kg(-1) day(-1) and then as an outpatient at 3 mg kg(-1) twice weekly for a further three weeks, a total of 40 mg kg(-1). Liposomal amphotericin offers a well-tolerated alternative to pentavalent antimony or amphotericin B deoxycholate for the systemic treatment of New World CL.