Construction of varicella-zoster virus recombinants from parent Oka cosmids and demonstration that ORF65 protein is dispensable for infection of human skin and T cells in the SCID-hu mouse model.


Niizuma, T; Zerboni, L; Sommer, MH; Ito, H; Hinchliffe, S; Arvin, AM; (2003) Construction of varicella-zoster virus recombinants from parent Oka cosmids and demonstration that ORF65 protein is dispensable for infection of human skin and T cells in the SCID-hu mouse model. Journal of virology, 77 (10). pp. 6062-5. ISSN 0022-538X DOI: https://doi.org/10.1128/JVI.77.10.6062-6065.2003

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Abstract

We generated an ORF65 deletion mutant by using a cosmid system constructed from the genome of a low-passage clinical isolate (P-Oka). Using the SCID-hu mouse model, we demonstrated that the ORF65 protein is dispensable for viral replication in skin and T cells, which are critical host cell targets during primary varicella-zoster virus infection.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 12719598
Web of Science ID: 182631100052
URI: http://researchonline.lshtm.ac.uk/id/eprint/13425

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