Analysis of immune activation and clinical events in acute infectious mononucleosis.


Williams, H; Macsween, K; McAulay, K; Higgins, C; Harrison, N; Swerdlow, A; Britton, K; Crawford, D; (2004) Analysis of immune activation and clinical events in acute infectious mononucleosis. The Journal of infectious diseases, 190 (1). pp. 63-71. ISSN 0022-1899 DOI: https://doi.org/10.1086/421276

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Abstract

The symptoms of infectious mononucleosis (IM) are thought to be caused by T cell activation and cytokine production. Surface lymphocyte activation marker (SLAM)-associated protein (SAP) regulates lymphocyte activation via signals from cell-surface CD244 (2B4) and SLAM (CD150). We followed T cell activation via this SAP/SLAM/CD244 pathway in IM and analyzed whether the results were associated with clinical severity. At diagnosis, SAP, SLAM, and CD244 were significantly up-regulated on CD4 and CD8 T cells; expression decreased during IM, but CD244 and SLAM levels remained higher on CD8 cells 40 days later. There were significantly more lymphocytes expressing CD8 and CD244/CD8 in patients with severe sore throat. The expression of CD8 alone and CD244 on CD8 cells correlated with increased virus load. We suggest that T cells expressing CD244 and SLAM are responsible for the clinical features of IM but that the control of activation is maintained by parallel increased expression of SAP.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health
PubMed ID: 15195244
Web of Science ID: 222002700008
URI: http://researchonline.lshtm.ac.uk/id/eprint/13399

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