DNA vaccines for biodefence

Garmory, HS; Perkins, SD; Phillpotts, RJ; Titball, RW; (2005) DNA vaccines for biodefence. Advanced drug delivery reviews, 57 (9). pp. 1343-1361. ISSN 0169-409X DOI: https://doi.org/10.1016/j.addr.2005.01.013

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The advantages associated with DNA vaccines include the speed with which they may be constructed and produced at large-scale, the ability to produce a broad spectrum of immune responses, and the ability for delivery using non-invasive means. In addition, DNA vaccines may be manipulated to express multiple antigens and may be tailored for the induction of appropriate immune responses. These advantages make DNA vaccination a promising approach for the development of vaccines for biodefence. In this review, the potential of DNA vaccines for biodefence is discussed. Crown Copyright (c) 2005 Published by Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: immunity, targeting, co-stimulatory molecules, delivery, carriers, regimens, viruses, bacteria, B surface-antigen, recombinant protective antigen, protein, transduction domains, equine encephalitis-virus, raised immune-, responses, cytotoxic t-lymphocyte, plasmid dna, antibody-, responses, gene-gun, yersinia-pestis
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Vaccine Centre
PubMed ID: 15935877
Web of Science ID: 230044000006
URI: http://researchonline.lshtm.ac.uk/id/eprint/13390


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