Nagot, Nicolas; Foulongne, Vincent; Becquart, Pierre; Mayaud, Philippe; Konate, Issouf; Ouedraogo, Abdoulaye; Defer, Marie-Christine; Weiss, Helen; Van de Perre, Philippe; Segondy, Michel; (2005) Longitudinal assessment of HIV-1 and HSV-2 shedding in the genital tract of West African women. Journal of acquired immune deficiency syndromes (1999), 39 (5). pp. 632-634. ISSN 1525-4135 https://researchonline.lshtm.ac.uk/id/eprint/13211
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https://researchonline.lshtm.ac.uk/id/eprint/13211
Abstract
Forty-two HSV-2-seropositive women, of whom 22 were HIV-1 seropositive, were followed up weekly for 3 weeks for assessment of HIV-1 and HSV-2 genital shedding in Bobo Dioulasso, Burkina Faso. HSV-2 DNA and HIV-1 RNA were quantitated in cervicovaginal lavages enriched with a cervical swabbing (eCVL) using real-time polymerase chain reaction. HIV-1 RNA shedding was detected in eCVL from 19 of 22 (86.4%) of the HIV-1-seropositive women and HSV-2 DNA was detected in eCVL from 12 of 42 (28.6%) of the women. Compared with the HIV-1-seronegative women, the HIV-1-seropositive women showed more persistent HSV-2 genital shedding and higher HSV-2 DNA loads in eCVL. This study showed that eCVL is a reliable sampling method for detecting both viruses. Three measurement points (at weekly intervals in this study) seem to adequately allow detection of most HIV-1 or HSV-2 genital shedders.
| Item Type | Article |
|---|---|
| Keywords | HIV-1 RNA, HSV-2 DNA, genital shedding, African women, Herpes-simplex-virus, swabbing procedures, type-2 infection, risk, rna, acquisition, fluids |
| Faculty and Department |
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology |
| Research Centre |
Centre for Maternal, Reproductive and Child Health (MARCH) Tropical Epidemiology Group |
| PubMed ID | 16044019 |
| ISI | 230976500020 |
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