Optimum time to start antiretroviral therapy in patients with HIV-associated tuberculosis (TB): before or after TB diagnosis?


Kerkhoff, AD; Wood, R; Lawn, SD; (2011) Optimum time to start antiretroviral therapy in patients with HIV-associated tuberculosis (TB): before or after TB diagnosis? AIDS (London, England). ISSN 0269-9370 DOI: https://doi.org/10.1097/QAD.0b013e328345ee32

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Abstract

World Health Organization policy states that tuberculosis (TB) should be diagnosed and treated before starting antiretroviral treatment (ART). However, during the pre-ART screening period, diagnosing or excluding TB can be a lengthy process and may cause undesirable delays in ART initiation. In this observational study from South Africa, we report that initiation of ART before TB treatment in patients with delayed diagnoses of culture-positive prevalent TB was not associated adverse clinical, immunological or virological outcomes during 12 months follow-up.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 21346513
Web of Science ID: 289458900015
URI: http://researchonline.lshtm.ac.uk/id/eprint/1315

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