AIDS in Africa: the impact of coinfections on the pathogenesis of HIV-1 infection.


Lawn, SD; (2004) AIDS in Africa: the impact of coinfections on the pathogenesis of HIV-1 infection. The Journal of infection, 48 (1). pp. 1-12. ISSN 0163-4453 DOI: https://doi.org/10.1016/j.jinf.2003.09.001

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Abstract

The intimate relationship between the HIV-1 life-cycle and the activation state of cells supporting viral replication results in a dynamic interaction between coinfections and HIV-1 replication in dually infected people. The immunologic impact of recurrent coinfections has the potential to increase viral replication, viral genotypic heterogeneity and CD4 T lymphocyte loss, leading to accelerated decline in immune function, reduced survival and increased HIV-1 transmission risk. These effects may play a particularly significant role in the HIV-1 epidemic in sub-Saharan Africa. The mechanisms underlying these effects on virus-host dynamics are reviewed and data describing the impact of tuberculosis, malaria, schistosomiasis and genital ulceration on HIV-1 infection are presented.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 14667787
Web of Science ID: 188163800001
URI: http://researchonline.lshtm.ac.uk/id/eprint/13029

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