Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British regional heart study


Lawlor, DA; Ebrahim, S; Whincup, P; Sterne, J; Papacosta, O; Wannamethee, G; Dhanjil, S; Griffin, M; Nicolaides, AN; Davey Smith, G; (2004) Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British regional heart study. Journal of epidemiology and community health, 58 (8). pp. 700-4. ISSN 0143-005X DOI: https://doi.org/10.1136/jech.2003.014001

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Abstract

OBJECTIVE: To determine the role of central adiposity in explaining sex differences in carotid intima media thickness (IMT). DESIGN: Cross sectional survey. SETTING: Two British towns. PARTICIPANTS: 800 men and women aged 56-75 years. MAIN OUTCOME MEASURES: Carotid IMT. RESULTS: There was a continuous linear association between waist-hip ratio and IMT in both men and women. The magnitude of the association between waist to hip ratio and IMT was identical in both sexes. In age adjusted analyses IMT was 14% greater in men compared with women (age adjusted male to female ratio of geometric means 1.14; 95% confidence interval 1.07 to 1.21) with adjustment for waist to hip ratio this attenuated to no difference (1.00; 0.92 to 1.09). Adjustment for body mass index and for lifestyle risk factors had very little effect on the sex difference in mean intima media thickness. CONCLUSIONS: Sex differences in body fat distribution may explain sex differences in arterial atherosclerosis.

Item Type: Article
Keywords: Aged, Body Constitution, Body Mass Index, Carotid Artery, Common/*anatomy & histology, Coronary Disease/etiology, Cross-Sectional Studies, England, Female, Humans, Male, Middle Aged, Research Support, Non-U.S. Gov't, Risk Factors, Sex Factors, Tunica Intima/*anatomy & histology, Aged, Body Constitution, Body Mass Index, Carotid Artery, Common, anatomy & histology, Coronary Disease, etiology, Cross-Sectional Studies, England, Female, Humans, Male, Middle Aged, Research Support, Non-U.S. Gov't, Risk Factors, Sex Factors, Tunica Intima, anatomy & histology
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 15252075
Web of Science ID: 222625400016
URI: http://researchonline.lshtm.ac.uk/id/eprint/12733

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