Neonatal BCG protection against tuberculosis lasts for 20 years in Brazil.


Barreto, ML; Cunha, SS; Pereira, SM; Genser, B; Hijjar, MA; Yury Ichihara, M; de Brito, SC; Dourado, I; Cruz, A; Santa'Ana, C; Rodrigues, LC; (2005) Neonatal BCG protection against tuberculosis lasts for 20 years in Brazil. The international journal of tuberculosis and lung disease , 9 (10). pp. 1171-3. ISSN 1027-3719

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Abstract

Bacille Calmette-Guérin (BCG) efficacy against pulmonary disease is highly variable; until very recently there was no evidence of protection after 10 years. In the control arm of a trial of efficacy of revaccination of schoolchildren in Brazil we found substantial protection (39%; 95%CI 9-58) of neonatal BCG against all forms of tuberculosis (TB) 15-20 years after vaccination, much longer than previously believed. This confirms recent findings from an earlier trial, and must be considered in the design of trials of new TB vaccines and in policy decisions based on assumed lack of neonatal BCG protection with time.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
Centre for Global Non-Communicable Diseases (NCDs)
Vaccine Centre
PubMed ID: 16229231
Web of Science ID: 232422100017
URI: http://researchonline.lshtm.ac.uk/id/eprint/12527

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