Differing spectrum of HIV-associated ophthalmic disease among patients starting antiretroviral therapy in India and South Africa.


Pathai, S; Gilbert, C; Weiss, HA; McNally, M; Lawn, SD; (2011) Differing spectrum of HIV-associated ophthalmic disease among patients starting antiretroviral therapy in India and South Africa. Tropical medicine & international health, 16 (3). pp. 356-9. ISSN 1360-2276 DOI: https://doi.org/10.1111/j.1365-3156.2010.02712.x

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Abstract

Differences in the prevalence and spectrum of HIV-associated ophthalmic disease in Africa and Asia are not well documented. We studied two comparable cohorts of patients initiating antiretroviral therapy in Mumbai, India, and Cape Town, South Africa. The prevalence of HIV-associated ophthalmic disease was higher in the Indian population (17.5%) than in the South African population (12.1%). This was largely because of vitreo-retinal opportunistic infections (11.4%vs. 2.6%, respectively), notably cytomegalovirus retinitis. This difference persisted after adjusting for confounding factors (adjusted odds ratio?=?11.32, 95% confidence interval: 2.67-48.13), confirming a marked geographical difference in the prevalence of HIV-associated retinal disease.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Tropical Epidemiology Group
The International Centre for Evidence in Disability
International Centre for Eye Health
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 21371217
Web of Science ID: 287823500013
URI: http://researchonline.lshtm.ac.uk/id/eprint/1241

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