Metalloantimalarials: Synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone


Gokhale, NH; Shirisha, K; Padhye, SB; Croft, SL; Kendrick, HD; McKee, V; (2006) Metalloantimalarials: Synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone. Bioorganic & medicinal chemistry letters, 16 (2). pp. 430-432. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2005.09.061

Full text not available from this repository.

Abstract

The crystal structure of copper (II) complex of 3-arylazo-4-hydroxy-1,2-naphthoquinone is reported. The in vitro antimalarial activity of analogous compounds against Plasmodium falciparum 3D7 strain reveals correlation with metal redox couple, suggesting component of parasitic electron transport chain as a possible target. (c) 2005 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: antimalarial activity, copper complexes, hydroxynaphthoquinone, metal, complexation, X-ray structure, Magnetic-properties, metal-complexes, semiquinone, ligands, agents
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 16275074
Web of Science ID: 233902200040
URI: http://researchonline.lshtm.ac.uk/id/eprint/12304

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
301Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item