Antimalarial and cytotoxic activities of chiral triamines

Dellai, A; Appel, J; Bouraoui, A; Croft, S; Nefzi, A; (2013) Antimalarial and cytotoxic activities of chiral triamines. Bioorganic & medicinal chemistry letters, 23 (16). pp. 4579-4582. ISSN 0960-894X DOI:

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Chiral triamine antimalarial compounds have been identified following the screening of mixture-based positional scanning libraries made up of 31,320 compounds against P. falciparum. The library, namely N-methyl triamine (TPI 762) was generated following exhaustive reduction of resin-bound acylated dipeptides. Using the PSCL approach, individual compounds were rapidly identified which were only 10 times less active than the standard drugs chloroquine (CQ) and Artemisinin (Artes). (C) 2013 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Chiral amines, Antimalrial, Malaria, Solid-phase organic synthesis, Libraries, Mixtures based libraries, Parallel synthesis, combinatorial chemistry, derivatives, libraries, diversity, trends
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 23835293
Web of Science ID: 322611900017


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