Antimalarial and cytotoxic activities of chiral triamines


Dellai, A; Appel, J; Bouraoui, A; Croft, S; Nefzi, A; (2013) Antimalarial and cytotoxic activities of chiral triamines. Bioorganic & medicinal chemistry letters, 23 (16). pp. 4579-4582. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2013.06.035

Full text not available from this repository.

Abstract

Chiral triamine antimalarial compounds have been identified following the screening of mixture-based positional scanning libraries made up of 31,320 compounds against P. falciparum. The library, namely N-methyl triamine (TPI 762) was generated following exhaustive reduction of resin-bound acylated dipeptides. Using the PSCL approach, individual compounds were rapidly identified which were only 10 times less active than the standard drugs chloroquine (CQ) and Artemisinin (Artes). (C) 2013 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Chiral amines, Antimalrial, Malaria, Solid-phase organic synthesis, Libraries, Mixtures based libraries, Parallel synthesis, combinatorial chemistry, derivatives, libraries, diversity, trends
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 23835293
Web of Science ID: 322611900017
URI: http://researchonline.lshtm.ac.uk/id/eprint/1229512

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
294Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item