Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age


Russell, FM; Carapetis, JR; Burton, RL; Lin, J; Licciardi, PV; Balloch, A; Tikoduadua, L; Waqatakirewa, L; Cheung, YB; Tang, MLK; Nahm, MH; Mulholland, EK; (2011) Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age. Vaccine, 29 (3). pp. 535-544. ISSN 0264-410X DOI: 10.1016/j.vaccine.2010.10.046

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Abstract

Opsonophagocytic activity (OPA) was measured following reduced infant doses of 7-valent pneumococcal conjugate vaccine (PCV-7) with or without 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months, and subsequent re-exposure to a small dose of pneumococcal polysaccharide antigens (mPPS) at 17 months. Fijian infants were randomized to receive 0, 1, 2, or 3 PCV-7 doses. Half received PPV-23 at 12 months and all received mPPS at 17 months. OPA was performed on up to 14 serotypes. Three and 2 PCV-7 doses resulted in similar OPA for most PCV-7 serotypes up to 9 months and for half of the serotypes at 12 months. A single dose improved OPA compared with the unvaccinated group. PPV-23 significantly improved OPA for all serotypes tested but in general, was associated with diminished responses following re-challenge. (C) 2010 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Pneumococcal vaccination, Opsonophagocytic activity, RANDOMIZED-CONTROLLED-TRIAL, ACUTE OTITIS-MEDIA, STREPTOCOCCUS-PNEUMONIAE, CAPSULAR POLYSACCHARIDES, ANTIBODY AVIDITY, DISEASE, IMMUNOGENICITY, ASSAY, MECHANISMS, REDUCTION
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
Vaccine Centre
PubMed ID: 21044669
Web of Science ID: 286853200024
URI: http://researchonline.lshtm.ac.uk/id/eprint/1227

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