Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents


Coro, J; Atherton, R; Little, S; Wharton, H; Yardley, V; Alvarez, A; Suarez, M; Perez, R; Rodriguez, H; (2006) Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents. Bioorganic & medicinal chemistry letters, 16 (5). pp. 1312-1315. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2005.11.060

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Abstract

The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b. rhodesiense with IC50 values ranging between 0.3 and 4 mu M for the most active compounds. (C) 2005 Elsevier Ltd. All rights reserved.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Leishmaniasis Group
PubMed ID: 16343898
Web of Science ID: 235284700044
URI: http://researchonline.lshtm.ac.uk/id/eprint/12105

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