Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen


Polley, R; Stager, S; Prickett, S; Maroof, A; Zubairi, S; Smith, DF; Kaye, PM; (2006) Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen. Infection and immunity, 74 (1). pp. 773-776. ISSN 0019-9567 DOI: https://doi.org/10.1128/IAI.74.1.773-776.2006

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Abstract

CD8(+) T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8(+) T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8(+) T cells is strictly dependent upon the presence of cognate antigen.

Item Type: Article
Keywords: Animals, Antigens, Protozoan, immunology, CD8-Positive T-Lymphocytes, immunology, Immunotherapy, Adoptive, Leishmania donovani, genetics, immunology, Leishmaniasis, Visceral, immunology, therapy, Mice, Mice, Transgenic, Ovalbumin, biosynthesis, genetics, Research Support, Non-U.S. Gov't
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Leishmaniasis Group
PubMed ID: 16369038
Web of Science ID: 234276400086
URI: http://researchonline.lshtm.ac.uk/id/eprint/12080

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