Current Issues for Anti-Malarial Drugs to Control P. falciparum Malaria.


Schellenberg, D; Abdulla, S; Roper, C; (2006) Current Issues for Anti-Malarial Drugs to Control P. falciparum Malaria. Current molecular medicine, 6 (2). pp. 253-60. ISSN 1566-5240 DOI: 10.2174/156652406776055168

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Abstract

Successful malaria control depends heavily on efficacious anti-malarial drugs for the treatment of malaria. Artesunate-containing Combination Treatments (ACT) are increasingly recommended as first line malaria treatment in endemic countries, but implementation of this recommendation is limited by the small number of available and affordable co-formulated anti-malarial drugs. In recent years Intermittent Preventive Treatment has been recommended for malaria control in pregnancy and has been shown to be of potential public health importance in the prevention of malaria and anaemia in children. The use of drugs for malaria treatment or prevention is associated with the development of resistance and recent advances in molecular biology facilitate the evaluation of the impact on drug resistance of new drug-based strategies. This review concentrates on the challenges surrounding the use of ACT, the current understanding of IPT in infants and the use of molecular approaches to enhance our understanding of the effects of interventions on the spread of drug resistance.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Antimicrobial Resistance Centre (AMR)
Malaria Centre
PubMed ID: 16515515
Web of Science ID: 236160600011
URI: http://researchonline.lshtm.ac.uk/id/eprint/12071

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