Rapid turnover of effector-memory CD4(+) T cells in healthy humans.


Macallan, DC; Wallace, D; Zhang, Y; De Lara, C; Worth, AT; Ghattas, H; Griffin, GE; Beverley, PC; Tough, DF; (2004) Rapid turnover of effector-memory CD4(+) T cells in healthy humans. The Journal of experimental medicine, 200 (2). pp. 255-60. ISSN 0022-1007 DOI: https://doi.org/10.1084/jem.20040341

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Abstract

Memory T cells can be divided into central-memory (T(CM)) and effector-memory (T(EM)) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not known whether they are maintained by similar mechanisms. We used in vivo labeling with deuterated glucose to measure the turnover of CD4(+) T cells in healthy humans. The CD45R0(+)CCR7(-) T(EM) subpopulation was shown to have a rapid proliferation rate of 4.7% per day compared with 1.5% per day for CD45R0(+)CCR7(+) T(CM) cells; these values are equivalent to average intermitotic (doubling) times of 15 and 48 d, respectively. In contrast, the CD45RA(+)CCR7(+) naive CD4(+) T cell population was found to be much longer lived, being labeled at a rate of only 0.2% per day (corresponding to an intermitotic time of approximately 1 yr). These data indicate that human CD4(+) T(EM) cells constitute a short-lived cell population that requires continuous replenishment in vivo.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
PubMed ID: 15249595
Web of Science ID: 222926000013
URI: http://researchonline.lshtm.ac.uk/id/eprint/12029

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