Association of body mass index measured in childhood, adolescence, and young adulthood with risk of ischemic heart disease and stroke: findings from 3 historical cohort studies.


Lawlor, DA; Martin, RM; Gunnell, D; Galobardes, B; Ebrahim, S; Sandhu, J; Ben-Shlomo, Y; McCarron, P; Davey Smith, G; (2006) Association of body mass index measured in childhood, adolescence, and young adulthood with risk of ischemic heart disease and stroke: findings from 3 historical cohort studies. The American journal of clinical nutrition, 83 (4). pp. 767-73. ISSN 0002-9165

Full text not available from this repository.

Abstract

BACKGROUND: It is unclear whether early life body mass index (BMI; in kg/m(2)) is associated with adult cardiovascular disease. OBJECTIVE: The objective was to assess the association of early life BMI with the risk of ischemic heart disease (IHD) and stroke. DESIGN: The association between early life BMI and risk of adult mortality from IHD and stroke was assessed in 3 historical cohort studies in which height and weight had been assessed by using standard procedures. Participants were traced and linked to national mortality data. Participants in the 3 cohorts were born between 1922 and 1937, 1927 and 1956, and 1928 and 1950 and were aged 2-15, 9-18, and 16-22 y, respectively, at the time of assessment of their height and weight. RESULTS: Participants in all 3 cohorts had mean BMIs similar to those reported for contemporary children and young adults, but fewer of the cohort participants were overweight or obese. BMI was not associated with future risk of IHD or stroke in any cohort. The pooled (all 3 cohorts) adjusted hazard ratio per SD of early life BMI was 1.09 (95% CI: 1.01, 1.19) for IHD and 0.94 (95% CI: 0.82, 1.08) for stroke. The pooled hazard ratio of IHD when participants who were overweight or obese for their age were compared with all other participants was 1.34 (95% CI: 0.95, 1.91), and no association was found between overweight or obesity and stroke risk. The effects of BMI did not vary by cohort or by age. CONCLUSION: These results do not provide strong evidence that being overweight or obese in childhood is associated with future cardiovascular disease risk.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 16600926
Web of Science ID: 236817100007
URI: http://researchonline.lshtm.ac.uk/id/eprint/12019

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
269Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item