The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: A new repertoire evolves over 12 months


Bennett, AR; Gorak-Stolinska, P; Ben-Smith, A; Floyd, S; de Lara, CM; Weir, RE; Lalor, MK; Makamo, K; Msiska, GK; Crampin, AC; Fine, PEM; Dockrell, HM; Beverley, PCL; (2006) The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: A new repertoire evolves over 12 months. Vaccine, 24 (14). pp. 2617-2626. ISSN 0264-410X DOI: 10.1016/j.vaccine.2005.12.011

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Abstract

Mycobacterium bovis bacille Calmette Guerin vaccination protects against pulmonary tuberculosis in the United Kingdom but not in Malawi. We investigated whether a difference in the clonal T-cell response to BCG vaccination might account for this. The results of clonal analysis were compared to those obtained by skin testing and in a whole blood interferon gamma assay. Pre-vaccination antigen specific T-cell clones were detected, but the majority of clones present 12 months after vaccination were not present earlier. The magnitude of the clonal response did not correlate well with results of the other assays. These data indicate that single assays may not be reliable and that a stable memory T-cell repertoire is slow to develop. (c) 2005 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: BCG, immunisation, clonality, Mycobacterium tuberculosis, Bone-marrow-transplantation, mycobacterium-bovis bcg, immune-responses, northern malawi, skin-test, environmental mycobacteria, heterologous, immunity, protective immunity, interferon-gamma, tuberculosis
Faculty and Department: Academic Services & Administration > Academic Administration
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: TB Centre
Vaccine Centre
MEIRU
Population Studies Group
PubMed ID: 16414159
Web of Science ID: 236259900020
URI: http://researchonline.lshtm.ac.uk/id/eprint/11964

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