Vaccination for vivax malaria: targeting the invaders.


Polley, SD; McRobert, L; Sutherland, CJ; (2004) Vaccination for vivax malaria: targeting the invaders. Trends in parasitology, 20 (3). pp. 99-102. ISSN 1471-4922 DOI: 10.1016/j.pt.2003.12.003

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Abstract

Among the surface-exposed antigens of the malaria parasite, those with known essential functions that can be disrupted by antibodies represent the most promising candidates for development as malaria vaccines. Two recombinant protein subunits of the Plasmodium vivax merozoite surface protein 1 have been shown to bind to reticulocytes in enzyme-linked immunosorbent assays. This article discusses the importance of such pre-clinical analyses in the validation of candidate vaccine molecules for P. vivax, given the constraints imposed by the use of primate models and the cost of producing suitable material for human trials.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Vaccine Centre
PubMed ID: 16676415
Web of Science ID: 220183900001
URI: http://researchonline.lshtm.ac.uk/id/eprint/11917

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