Serosurvey on household contacts of marburg hemorrhagic fever patients.


Borchert, M; Mulangu, S; Swanepoel, R; Libande, ML; Tshomba, A; Kulidri, A; Muyembe-Tamfum, JJ; Van der Stuyft, P; (2006) Serosurvey on household contacts of marburg hemorrhagic fever patients. Emerging infectious diseases, 12 (3). pp. 433-9. ISSN 1080-6040 DOI: https://doi.org/10.3201/eid1205.050622

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Abstract

: The first major outbreak of Marburg hemorrhagic fever (MHF) outside a laboratory environment occurred in the subdistrict of Watsa, Democratic Republic of Congo, from October 1998 to August 2000. We performed a serosurvey of household contacts of MHF patients to identify undetected cases, ascertain the frequency of asymptomatic Marburg infection, and estimate secondary attack risk and postintervention reproduction number. Contacts were interviewed about their exposure and symptoms consistent with MHF. Blood samples were tested for anti-Marburg immunoglobulin G (IgG). One hundred twenty-one (51%) of 237 identified contacts participated; 72 (60%) were not known to the health authorities. Two participating contacts were seropositive and reported becoming ill after the contact; no serologic evidence for asymptomatic or mild Marburg infection was found. The secondary attack risk was 21%; the postintervention reproduction number was 0.9, consistent with an outbreak sustained by repeated primary transmission, rather than large-scale secondary transmission.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 16704781
Web of Science ID: 235922300011
URI: http://researchonline.lshtm.ac.uk/id/eprint/11894

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