A case-control study of protection against tuberculosis by BCG revaccination in Recife, Brazil.

Dantas, OM; Ximenes, RA; de Albuquerque, MdeF; da Silva, NL; Montarroyos, UR; de Souza, WV; Pereira, TC; Campelo, AR; Rodrigues, LC; (2006) A case-control study of protection against tuberculosis by BCG revaccination in Recife, Brazil. The international journal of tuberculosis and lung disease, 10 (5). pp. 536-41. ISSN 1027-3719

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SETTING: Metropolitan region of Recife, Brazil. OBJECTIVE: To estimate the additional protection against tuberculosis (TB) provided by a second dose of bacille Calmette-Guérin (BCG) vaccine. DESIGN: Case-control study. Cases were cases of TB newly diagnosed by the TB control programme, independent of clinical form. Three matched neighbourhood controls were selected using a systematic routine, starting from the case's address. The matching was within the age groups 7-9, 10-14 and 15-19 years. RESULTS: Analysis was conducted among 169 cases and 477 controls. For the efficacy of BCG revaccination against TB overall, matched (crude) vaccine effectiveness (VE) was -3 (95% CI -50-29) and matched (adjusted) VE was 8 (95% CI -77-52). CONCLUSIONS: This study suggests that a second dose of BCG does not offer additional protection. Revaccination should not be offered. As large numbers of subjects are already vaccinated and vaccine appears to offer some protection in older subjects, further studies with larger sample sizes could investigate the potential efficacy of revaccination with BCG in the age group > or = 15 years.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Vaccine Centre
PubMed ID: 16704036
Web of Science ID: 237216500011
URI: http://researchonline.lshtm.ac.uk/id/eprint/11873


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