Beijing/W genotype Mycobacterium tuberculosis and drug resistance


Glynn, JR; Kremer, K; Borgdorff, MW; Rodriguez, MP; van Soolingen, D; (2006) Beijing/W genotype Mycobacterium tuberculosis and drug resistance. Emerging infectious diseases, 12 (5). pp. 736-743. ISSN 1080-6040

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Abstract

Beijing/W genotype Mycobacterium tuberculosis is widespread, may be increasing, and may have a predilection for drug resistance. Individual-level data on > 29,000 patients from 49 studies in 35 countries were combined to assess the Beijing genotype's prevalence worldwide, trends over time and with age, and associations with drug resistance. We found 4 patterns for Beijing/W genotype tuberculosis (TB): 1) endemic, not associated with drug resistance (high level in most of East Asia, lower level in parts of the United States); 2) epidemic, associated with drug resistance (high level in Cuba, the former Soviet Union, Vietnam, and South Africa, lower level in parts of Western Europe); 3) epidemic but drug sensitive (Malawi, Argentina); and 4) very low level or absent (parts of Europe, Africa). This study confirms that Beijing/W genotype TB is an emerging pathogen in several areas and a predominant endemic strain in others; it is frequently associated with drug resistance.

Item Type: Article
Keywords: Molecular epidemiology, prison-inmates, united-states, clone family, new-york, strain, spread, identification, predominance, transmission
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Antimicrobial Resistance Centre (AMR)
TB Centre
Web of Science ID: 237187200004
URI: http://researchonline.lshtm.ac.uk/id/eprint/11832

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