Folic Acid treatment of zambian children with moderate to severe malaria anemia.


Mulenga, M; Malunga, P; Bennett, S; Thuma, P; Shulman, C; Fielding, K; Greenwood, B; (2006) Folic Acid treatment of zambian children with moderate to severe malaria anemia. The American journal of tropical medicine and hygiene, 74 (6). pp. 986-90. ISSN 0002-9637

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Abstract

: Whether administration of folic acid to children with malaria anemia is helpful is controversial. Therefore, we conducted a randomised, placebo-controlled trial of 14 days of treatment with folic acid (1 mg/d) in Zambian children with malaria anemia treated with either sulfadoxine/pyrimethamine (SP) or atovaquone/proguanil (AP). Among children who received SP, the prevalence of parasitemia was higher in children treated with folic acid than among those given placebo at days 3, 7, and 14 after the start of treatment, and the difference at day 3 was statistically significant (P = 0.013). Folic acid treatment had no effect on parasitemia in children treated with AP. Administration of folic acid led to a small increase in packed cell volume over that seen in the placebo group at days 14 and 28 after the start of treatment.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Malaria Centre
Tropical Epidemiology Group
PubMed ID: 16760508
Web of Science ID: 238200900011
URI: http://researchonline.lshtm.ac.uk/id/eprint/11813

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