Parental smoking and lung function in children: an international study.


Moshammer, H; Hoek, G; Luttmann-Gibson, H; Neuberger, MA; Antova, T; Gehring, U; Hruba, F; Pattenden, S; Rudnai, P; Slachtova, H; Zlotkowska, R; Fletcher, T; (2006) Parental smoking and lung function in children: an international study. American journal of respiratory and critical care medicine, 173 (11). pp. 1255-63. ISSN 1073-449X DOI: https://doi.org/10.1164/rccm.200510-1552OC

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Abstract

RATIONALE: Both prenatal and postnatal passive smoking have been linked with respiratory symptoms and asthma in childhood. Their differential contributions to lung function growth in the general children's population are less clear. OBJECTIVE: To study the relative impact of pre- and postnatal exposure on respiratory functions of primary school children in a wide range of geographic settings, we analyzed flow and volume data of more than 20,000 children (aged 6-12 yr) from nine countries in Europe and North America. METHODS: Exposure information had been obtained by comparable questionnaires, and spirometry followed a protocol of the American Thoracic Society/European Respiratory Society. Linear and logistic regressions were used, controlling for individual risk factors and study area. Heterogeneity between study-specific results and mean effects were estimated using meta-analytic tools. MAIN RESULTS: Smoking during pregnancy was associated with decreases in lung function parameters between -1% (FEV1) and -6% maximal expiratory flow at 25% of vital capacity left (MEF25). A 4% lower maximal midexpiratory flow (MMEF) corresponded to a 40% increase in the risk of poor lung function (MMEF < 75% of expected). Associations with current passive smoking were weaker though still measurable, with effects ranging from -0.5% (FEV1) to -2% maximal expiratory flow (MEF50). CONCLUSIONS: Considering the high number of children exposed to maternal smoking in utero and the even higher number exposed to passive smoking after birth, this risk factor for reduced lung function growth remains a serious pediatric and public health issue.

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
PubMed ID: 16484675
Web of Science ID: 237990100014
URI: http://researchonline.lshtm.ac.uk/id/eprint/11795

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