New findings in the pathogenesis of leprosy and implications for the management of leprosy.


Polycarpou, A; Walker, SL; Lockwood, DN; (2013) New findings in the pathogenesis of leprosy and implications for the management of leprosy. Current opinion in infectious diseases, 26 (5). pp. 413-9. ISSN 0951-7375 DOI: https://doi.org/10.1097/QCO.0b013e3283638b04

Full text not available from this repository. (Request a copy)

Abstract

PURPOSE OF REVIEW This review focuses on recent work in leprosy pathogenesis. New research of both innate and adaptive immune responses to Mycobacterium leprae is described. The proposition that Mycobacterium lepromatosis is a new species causing leprosy is discussed. RECENT FINDINGS Modulation of the lipid metabolism and reprogramming of adult Schwann cells have both been suggested as mechanisms used by M. leprae to disseminate the disease. New markers associated with localized, disseminated disease or the occurrences of leprosy reactions include the human interferons, CD163, microRNA-21, NOD2, galectin-3 and toll-like receptor 4. The role of keratinocytes instead of macrophages is underlined in the pathogenesis of leprosy. Adaptive immunity reports focus on the role of T regulatory cells and cytokines secreted by T helper cells in leprosy. Finally, a newly identified species named M. lepromatosis has been detected in patients with leprosy and severe erythema nodosum leprosum. SUMMARY Novel biological pathways have been identified to be associated with the clinical phenotype of leprosy or the occurrence of leprosy reactions. Future work should include larger numbers of clinical samples from across the leprosy spectrum in order to give new insights in the pathogenesis and management of the disease.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Neglected Tropical Diseases Network
PubMed ID: 23982232
Web of Science ID: 326810600003
URI: http://researchonline.lshtm.ac.uk/id/eprint/1179144

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
305Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item