The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection


Tanabe, M; Atkins, HS; Harland, DN; Elvin, SJ; Stagg, AJ; Mirza, O; Titball, RW; Byrne, B; Brown, KA; (2006) The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection. Infection and immunity, 74 (6). pp. 3687-3691. ISSN 0019-9567 DOI: 10.1128/IAI.01837-05

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Abstract

The identification of Yersinia pestis as a potential bioterrorism agent and the emergence of antibiotic-resistant strains have highlighted the need for improved vaccines and treatments for plague. The aim of this study was to evaluate the potential for ATP-binding cassette (ABC) transporter proteins to be exploited as novel vaccines against plague. Western blotting of ABC transporter proteins using sera from rabbits immunized with killed whole Y. pestis cells or human convalescent-phase sera identified four immunologically reactive proteins: OppA, PstS, YrbD, and PiuA. Mice immunized with these proteins developed antibody to the immunogen. When the immunized mice were challenged with Y. pestis, the OppA-immunized mice showed an increased time to death compared to other groups, and protection appeared to correlate with the level of immunoglobulin G antibody to OppA.

Item Type: Article
Keywords: Oligopeptide permease, escherichia-coli, peptide-transport, pneumonic, plague, iron uptake, vaccine, immunization, virulence, system, model, Adjuvants, Immunologic, pharmacology, Animals, Antibodies, Bacterial, blood, Bacterial Proteins, immunology, Blotting, Western, Carrier Proteins, immunology, Enzyme-Linked Immunosorbent Assay, Female, Immune Sera, immunology, Immunization, Immunoglobulin G, classification, Lipoproteins, immunology, Mice, Mice, Inbred BALB C, Plague, prevention & control, Plague Vaccine, immunology, Research Support, Non-U.S. Gov't, Yersinia pestis, immunology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 16714605
Web of Science ID: 237862100071
URI: http://researchonline.lshtm.ac.uk/id/eprint/11752

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