Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection.


Dawes, R; Hennig, B; Irving, W; Petrova, S; Boxall, S; Ward, V; Wallace, D; Macallan, DC; Thursz, M; Hill, A; Bodmer, W; Beverley, PC; Tchilian, EZ; (2006) Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection. Journal of medical genetics, 43 (8). pp. 678-84. ISSN 0022-2593 DOI: https://doi.org/10.1136/jmg.2005.040485

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Abstract

BACKGROUND: A polymorphism in exon 4 (C77G) of CD45 that alters CD45 splicing has been associated with autoimmune and infectious diseases in humans. OBJECTIVE: To investigate the effect of C77G in hepatitis C virus (HCV) infected individuals and study the phenotype and function of peripheral blood mononuclear cells (PBMC) from healthy and hepatitis C infected C77G carriers. RESULTS: C77G individuals showed an increased proportion of primed CD45RA and effector memory CD8 T cells and more rapid activation of the lymphocyte specific protein tyrosine kinase (Lck) following CD3 stimulation. Transgenic mice with CD45 expression mimicking that in human C77G variants had more activated/memory T cells, more rapid proliferative responses, and activation of Lck. CONCLUSIONS: Changes in CD45 isoform expression can alter immune function in human C77G variants and CD45 transgenic mice. The C77G allele may influence the outcome of HCV infection.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 16505159
Web of Science ID: 239433100008
URI: http://researchonline.lshtm.ac.uk/id/eprint/11659

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